Pearl accessories are generally safe to wear for most people, but just like with any jewelry, there are a few things to consider if you're worried about allergies:

1. Metal Sensitivities:
   While pearls themselves are unlikely to cause an allergy, the metal used in the setting of the pearls could trigger sensitivities. If you have a metal allergy, especially to nickel or certain alloys, you might experience irritation when wearing pearl earrings, necklaces, or bracelets. In this case, choosing pieces made with hypoallergenic metals like 925 sterling silver or 14K gold can help reduce the risk of irritation.

2. Coatings and Treatments:
   Some pearl jewelry may be treated or coated with certain chemicals for durability or shine. Although rare, certain chemicals used in treatments could cause skin irritation for sensitive individuals. If you’re concerned, opt for natural pearls that haven't been treated with harsh chemicals.

3. Pearl Irritation:
   It's important to note that pearls are organic gems. They're composed of calcium carbonate and other natural elements, so in rare cases, very sensitive skin might react to the oils or irritants on the surface of the pearls. To avoid this, ensure your pearl jewelry is kept clean, and always remove it before applying lotions, perfumes, or other products that might cause a reaction.

4. Caring for Sensitive Skin:
   If you're prone to skin allergies or irritation, it's advisable to test a small amount of the jewelry first, perhaps by wearing it for short periods to see how your skin reacts. If irritation occurs, removing the jewelry and giving your skin time to heal is crucial.

In general, pearl jewelry is considered safe for most people, but if you have concerns about allergies, selecting hypoallergenic options and ensuring the pieces are made from natural, untreated pearls can help make your experience more comfortable.